Inhibition of specific epitranscriptomic modifiers can lead to stabilization of various RNA molecules. In the case of mutated RNA transcripts, such stabilization may prevent nonsense mediated decay (NMD). This can potentially lead to expression of partially functional proteins in the case of various rare diseases, or to increase in RNA load in NMD-dependent cancers.

link to RNAble page

AML, rare disease

Prof. Rotem Karni – Inventor

Amir Mor, PhD – CSO